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1996-02-27
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Document 0635
DOCN M9630635
TI The effects of HIV on cognitive and motor development in children born
to HIV-seropositive women with no reported drug use: birth to 24 months.
DT 9603
AU Gay CL; Armstrong FD; Cohen D; Lai S; Hardy MD; Swales TP; Morrow CJ;
Scott GB; Department of Pediatrics, University of Miami School of
Medicine,; FL 33101, USA.
SO Pediatrics. 1995 Dec;96(6):1078-82. Unique Identifier : AIDSLINE
MED/96095157
AB OBJECTIVE. This study documents delays in the mental and motor
functioning of infants perinatally infected with human immunodeficiency
virus (HIV) while controlling for confounding effects of prenatal drug
exposure, ethnicity, socioeconomic status, and maternal separation and
death. METHODS. The cognitive and motor development of 126 infants born
to nondrug-using, HIV-seropositive Haitian women was assessed at 3-month
intervals through 24 months of age using the Bayley Scales of Infant
Development. By 18 months of age, 28 of the infants were diagnosed as
HIV-infected, and the 98 uninfected infants served as a control group.
The infected and uninfected infants did not differ with respect to mean
gestational age, birth weight, ethnicity, or rates of maternal
separation and death. RESULTS. By 3 months of age, the mean mental and
motor scores of the infected infants were significantly lower than those
of the uninfected controls. Furthermore, the initial differences between
the two groups increased over time, as many of the infected infants
became increasingly delayed. Although the infected infants tended to
perform more poorly than the uninfected infants, nearly one third of the
infected infants exhibited relatively normal cognitive development and
half demonstrated relatively normal motor development. CONCLUSIONS. Over
the first 24 months of life, the mean rate of development of
HIV-infected infants is significantly slower than that of noninfected
infants born to seropositive mothers. This occurs even when the effects
are not confounded with those of prenatal drug exposure.
DE Adult *Child Development Child, Preschool *Cognition Comparative
Study Female Florida Haiti/ETHNOLOGY Human HIV
Infections/*PSYCHOLOGY HIV Seropositivity/*PSYCHOLOGY
HIV-1/*IMMUNOLOGY Infant Infant, Newborn Male Psychological
Tests/STATISTICS & NUMER DATA *Psychomotor Performance Substance Abuse
Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).